What should a nurse inform a couple about clomiphene treatment for infertility?

The correct response emphasizes the potential for multiple births, which is an important consideration for couples undergoing clomiphene treatment for infertility. Clomiphene citrate is a medication that stimulates ovulation by influencing hormonal pathways, and its use can lead to the release of multiple eggs during a single cycle. As a result, there is an increased risk of multiple gestation—such as twins or higher-order multiples—compared to natural conception. This factor is crucial for couples to understand as it can significantly impact their pregnancy experience and is important for their planning and expectations.

The other options address different aspects but do not hold the same relevance in this context. While breast engorgement is typically not a side effect associated with clomiphene, the administration of the medication is generally oral rather than IV, making those responses less pertinent to understanding the implications of clomiphene treatment. Engaging in coitus at least once a week can be beneficial in a broader infertility context, but it is not specifically tied to the mechanics or risks of clomiphene treatment itself as directly as the risk of multiple births.